High Dose MTX Exposure Prediction
Leukemia Protocols
5 g/m
2
over 24 hrs
1 g/m
2
over 24 hrs
1 g/m
2
over 4 hrs
2 g/m
2
over 2 hrs
200 mg/m
2
over 15 mins
Osteosarcoma Protocols
12 g/m
2
over 4 hrs
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Osteosarcoma Protocols
Figure Legend
Black Curve:
Median MTX Concentration
Blue Shaded Region:
25
th
to 75
th
percentiles of MTX Concentration
Grey Shaded Region:
1
st
to 99
th
percentiles of MTX Concentration
Dose (mg/m2)
12000
Infusion Length (hrs)
4
1
st
Ptile
25
th
Ptile
median
75
th
Ptile
99
th
Ptile
CL (ml/min/m2)
13.59
42.24
51.30
60.17
103.17
V (L/m2)
3.88
8.63
10.03
11.55
20.11
Ke (1/hrs)
0.14
0.27
0.31
0.34
0.50
Kcp (1/hrs)
0.00004
0.00183
0.00361
0.00690
0.03961
Kpc (1/hrs)
0.00107
0.04656
0.07598
0.10095
0.20317
AUC (uM hr)
4353.09
7349.77
8642.49
10403.02
28720.55
4 hr conc. (end of infusion) (uM)
757.64
1281.39
1486.33
1737.53
3498.39
24 hr. conc. (uM)
1.13
3.34
5.56
9.99
139.39
44 hr. conc. (uM)
0.12
0.32
0.46
0.73
10.88
Percentage with 44 hr concentration >1.0 uM
15.0%
