High Dose MTX Exposure Prediction
Leukemia Protocols
5 g/m
2
over 24 hrs
1 g/m
2
over 24 hrs
1 g/m
2
over 4 hrs
2 g/m
2
over 2 hrs
200 mg/m
2
over 15 mins
Osteosarcoma Protocols
12 g/m
2
over 4 hrs
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Leukemia Protocols
Figure Legend
Black Curve:
Median MTX Concentration
Blue Shaded Region:
25
th
to 75
th
percentiles of MTX Concentration
Grey Shaded Region:
1
st
to 99
th
percentiles of MTX Concentration
Dose (mg/m
2
)
5000
Infusion Length (hrs)
24
1
st
Percentile
25
th
Percentile
Median
75
th
Percentile
99
th
Percentile
CL (ml/min/m
2
)
57.4
94.6
111.9
130.8
196.1
V (L/m
2
)
8.6
10.9
11.6
12.3
19.1
Ke (1/hrs)
0.28
0.52
0.58
0.65
0.85
Kcp (1/hrs)
0.01
0.02
0.03
0.05
0.12
Kpc (1/hrs)
0.10
0.11
0.11
0.12
0.12
AUC (uM hr)
939.1
1410.6
1637.5
1934.5
3190.6
24 hr conc. (end of infusion) (uM)
35.5
53.7
61.6
73.5
116.9
44 hr. conc. (uM)
0.14
0.34
0.50
0.82
5.95
Percentage with 44 hr concentration >1.0 uM
18.1%
