Leukemia Protocols
Figure Legend Black Curve: Median MTX Concentration
Blue Shaded Region: 25th to 75th percentiles of MTX Concentration
Grey Shaded Region: 1st to 99th percentiles of MTX Concentration
Dose (mg/m2) 5000
Infusion Length (hrs) 24
1st Percentile 25th Percentile Median 75th Percentile 99th Percentile
CL (ml/min/m2) 57.4 94.6 111.9 130.8 196.1
V (L/m2) 8.6 10.9 11.6 12.3 19.1
Ke (1/hrs) 0.28 0.52 0.58 0.65 0.85
Kcp (1/hrs) 0.01 0.02 0.03 0.05 0.12
Kpc (1/hrs) 0.10 0.11 0.11 0.12 0.12
AUC (uM hr) 939.1 1410.6 1637.5 1934.5 3190.6
24 hr conc. (end of infusion) (uM) 35.5 53.7 61.6 73.5 116.9
44 hr. conc. (uM) 0.14 0.34 0.50 0.82 5.95
Percentage with 44 hr concentration >1.0 uM 18.1%